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Canagliflozin (INN, trade name Invokana) is a drug of the gliflozin class, used for the treatment of type 2 diabetes. It was developed by Mitsubishi Tanabe Pharma and is marketed under license by Janssen, a division of Johnson & Johnson.
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Canagliflozin has proven to be clinically effective in people with moderate renal failure and treatment can be continued in patients with renal impairment.
As is common with all SGLT-2 inhibitors, Canagliflozin is assocaited with increased urinary tract infections, fungal infections of the genital area, increased thirst, elevations in LDL cholesterol, increased urination and episodes of low blood pressure. There are concerns it may also increase the risk of diabetic ketoacidosis.
The drug may increase the risk of dehydration in combination with diuretic drugs.